CURATED BLOCKED QUESTION

Randomised trials of lifetime dietary exposure in humans

Most claims about long-term diet rest on observational cohorts with well-known confounding. The trial that would settle them — randomising people to decades of controlled intake — cannot ethically be run, and compliance would not survive it. The uncertainty is structural, not a gap in anyone's ideas.

blocked by

ethics

This is a sourced, human-curated entry or a declared project limitation. It is not a computed discovery or an actionable hypothesis.