{ "schema_version": 1, "id": "replicated-expression-evidence-v1-result", "state": "replicated_observations_published", "verdict": "measured", "protocol": { "id": "replicated-expression-association-v1", "canonical_json_sha256": "029b23a5e0a02755354e88b48177e13b90faee90a8b270fb9225790fa1e51d2f" }, "source_manifest": { "path": "../benchmarks/evidence/source-v1.json", "canonical_json_sha256": "7547ae062bd65ea986491c6d5ac60c6435b66d728b7079e26334787635737233" }, "candidate_universe": { "path": "../benchmarks/evidence/candidate-universe-v1.json", "canonical_json_sha256": "ce2c3ce250cc015bcd9b49e039887da1147fcbd9d82d67c2ca7c3d9b817e34c6" }, "full_pair_table": { "filename": "replicated-association-v1-pairs.tsv.gz", "sha256": "040b0f28a9b5a2978a250da634bf484d75eb796bdbc962a59a639f80a78f6452", "row_count": 499500, "committed": false, "local_verification_required_for_byte_level_replay": true }, "cohorts": [ { "id": "tcga_brca_pancan_2018_expression", "study_id": "brca_tcga_pan_can_atlas_2018", "platform": "batch_normalized_illumina_hiseq_rnaseqv2_rsem", "sample_count": 1082, "analyzable_gene_count": 997 }, { "id": "metabric_brca_expression", "study_id": "brca_metabric", "platform": "illumina_ht12_v3_microarray_log2_intensity", "sample_count": 1980, "analyzable_gene_count": 999 } ], "gates": { "source_integrity": "passed", "sample_independence": "passed", "power": "passed", "null_calibration": "passed", "null_pass_count": 0, "maximum_null_pass_count": 5 }, "numeric_bounds": { "p_value_floor": 2.2250738585072014e-308, "policy": "p-values below the float64 smallest positive normal are clamped before BH; affected exported q-values are conservative, not exact zeros", "measured_p_values_clamped": { "tcga_brca_pancan_2018_expression": 25, "metabric_brca_expression": 86 }, "permuted_null_p_values_clamped": { "tcga_brca_pancan_2018_expression": 0, "metabric_brca_expression": 0 } }, "counts": { "tested_pairs": 499500, "replicated_pairs": 1599, "published_observations": 100 }, "observations": [ { "rank": 1, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 9789, "symbol": "SPCS2" }, "b": { "entrez_gene_id": 653566, "symbol": "SPCS2P4" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.87462175, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.89216618, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for SPCS2 (Entrez 9789) and SPCS2P4 (Entrez 653566) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 2, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.9039092, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.8709027, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for ARHGAP9 (Entrez 64333) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 3, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 699, "symbol": "BUB1" }, "b": { "entrez_gene_id": 9833, "symbol": "MELK" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.88189962, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.86445659, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for BUB1 (Entrez 699) and MELK (Entrez 9833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 4, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 9833, "symbol": "MELK" }, "b": { "entrez_gene_id": 113130, "symbol": "CDCA5" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.83928514, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.88231924, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for MELK (Entrez 9833) and CDCA5 (Entrez 113130) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 5, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3833, "symbol": "KIFC1" }, "b": { "entrez_gene_id": 113130, "symbol": "CDCA5" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.85943829, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.82714065, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for KIFC1 (Entrez 3833) and CDCA5 (Entrez 113130) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 6, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 699, "symbol": "BUB1" }, "b": { "entrez_gene_id": 113130, "symbol": "CDCA5" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.8190936, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.85047711, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for BUB1 (Entrez 699) and CDCA5 (Entrez 113130) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 7, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 83706, "symbol": "FERMT3" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.82746454, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.80854843, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for FERMT3 (Entrez 83706) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 8, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3833, "symbol": "KIFC1" }, "b": { "entrez_gene_id": 9833, "symbol": "MELK" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.84454128, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.80842275, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for KIFC1 (Entrez 3833) and MELK (Entrez 9833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 9, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.79975231, "benjamini_hochberg_q_conservative": 9.565270685287502e-281 }, "metabric": { "samples": 1980, "spearman_rho": 0.82291798, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for ARHGAP9 (Entrez 64333) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 10, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3108, "symbol": "HLA-DMA" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.8287724, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.79886119, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HLA-DMA (Entrez 3108) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 11, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 56833, "symbol": "SLAMF8" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.79113573, "benjamini_hochberg_q_conservative": 7.83012608588487e-269 }, "metabric": { "samples": 1980, "spearman_rho": 0.8145179, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for SLAMF8 (Entrez 56833) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 12, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 699, "symbol": "BUB1" }, "b": { "entrez_gene_id": 3833, "symbol": "KIFC1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.8091075, "benjamini_hochberg_q_conservative": 1.9768846714425857e-294 }, "metabric": { "samples": 1980, "spearman_rho": 0.79048752, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for BUB1 (Entrez 699) and KIFC1 (Entrez 3833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 13, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 83706, "symbol": "FERMT3" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.80549797, "benjamini_hochberg_q_conservative": 5.116727455085235e-289 }, "metabric": { "samples": 1980, "spearman_rho": 0.78197431, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for FERMT3 (Entrez 83706) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 14, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.79841088, "benjamini_hochberg_q_conservative": 7.55149003350153e-279 }, "metabric": { "samples": 1980, "spearman_rho": 0.78194204, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for ARHGAP9 (Entrez 64333) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 15, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 63940, "symbol": "GPSM3" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.79712222, "benjamini_hochberg_q_conservative": 4.830104835757919e-277 }, "metabric": { "samples": 1980, "spearman_rho": 0.7762963, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GPSM3 (Entrez 63940) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 16, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 699, "symbol": "BUB1" }, "b": { "entrez_gene_id": 3161, "symbol": "HMMR" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.81138061, "benjamini_hochberg_q_conservative": 6.926614186045765e-298 }, "metabric": { "samples": 1980, "spearman_rho": 0.77401718, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for BUB1 (Entrez 699) and HMMR (Entrez 3161) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 17, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.80030518, "benjamini_hochberg_q_conservative": 1.5840608442311052e-281 }, "metabric": { "samples": 1980, "spearman_rho": 0.76477605, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for ARHGAP9 (Entrez 64333) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 18, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 699, "symbol": "BUB1" }, "b": { "entrez_gene_id": 7153, "symbol": "TOP2A" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.80445641, "benjamini_hochberg_q_conservative": 1.7371741302121946e-287 }, "metabric": { "samples": 1980, "spearman_rho": 0.76420701, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for BUB1 (Entrez 699) and TOP2A (Entrez 7153) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 19, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3108, "symbol": "HLA-DMA" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.81127768, "benjamini_hochberg_q_conservative": 9.660752126414421e-298 }, "metabric": { "samples": 1980, "spearman_rho": 0.75802908, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HLA-DMA (Entrez 3108) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 20, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3108, "symbol": "HLA-DMA" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.78488756, "benjamini_hochberg_q_conservative": 1.1263822231020313e-260 }, "metabric": { "samples": 1980, "spearman_rho": 0.75741506, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HLA-DMA (Entrez 3108) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 21, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 83706, "symbol": "FERMT3" }, "b": { "entrez_gene_id": 126014, "symbol": "OSCAR" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.76551594, "benjamini_hochberg_q_conservative": 2.963923820217395e-237 }, "metabric": { "samples": 1980, "spearman_rho": 0.75433595, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for FERMT3 (Entrez 83706) and OSCAR (Entrez 126014) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 22, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3627, "symbol": "CXCL10" }, "b": { "entrez_gene_id": 56833, "symbol": "SLAMF8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.7737836, "benjamini_hochberg_q_conservative": 6.83215441159104e-247 }, "metabric": { "samples": 1980, "spearman_rho": 0.7513853, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CXCL10 (Entrez 3627) and SLAMF8 (Entrez 56833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 23, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 6363, "symbol": "CCL19" }, "b": { "entrez_gene_id": 51316, "symbol": "PLAC8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.77348133, "benjamini_hochberg_q_conservative": 1.530559549684494e-246 }, "metabric": { "samples": 1980, "spearman_rho": 0.74714295, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CCL19 (Entrez 6363) and PLAC8 (Entrez 51316) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 24, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 63940, "symbol": "GPSM3" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.79114518, "benjamini_hochberg_q_conservative": 7.772934241847037e-269 }, "metabric": { "samples": 1980, "spearman_rho": 0.74476692, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GPSM3 (Entrez 63940) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 25, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 7153, "symbol": "TOP2A" }, "b": { "entrez_gene_id": 9833, "symbol": "MELK" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.74291847, "benjamini_hochberg_q_conservative": 3.153021819054646e-213 }, "metabric": { "samples": 1980, "spearman_rho": 0.76881714, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for TOP2A (Entrez 7153) and MELK (Entrez 9833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 26, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 4332, "symbol": "MNDA" }, "b": { "entrez_gene_id": 54504, "symbol": "CPVL" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.7405341, "benjamini_hochberg_q_conservative": 7.172780921781629e-211 }, "metabric": { "samples": 1980, "spearman_rho": 0.75677267, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for MNDA (Entrez 4332) and CPVL (Entrez 54504) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 27, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 958, "symbol": "CD40" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.77023546, "benjamini_hochberg_q_conservative": 1.061173072645319e-242 }, "metabric": { "samples": 1980, "spearman_rho": 0.73401036, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CD40 (Entrez 958) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 28, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3833, "symbol": "KIFC1" }, "b": { "entrez_gene_id": 27338, "symbol": "UBE2S" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.72974992, "benjamini_hochberg_q_conservative": 1.3252844110414208e-200 }, "metabric": { "samples": 1980, "spearman_rho": 0.74519125, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for KIFC1 (Entrez 3833) and UBE2S (Entrez 27338) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 29, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 83706, "symbol": "FERMT3" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.7827019, "benjamini_hochberg_q_conservative": 6.933028120522975e-258 }, "metabric": { "samples": 1980, "spearman_rho": 0.7295851, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for FERMT3 (Entrez 83706) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 30, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 1462, "symbol": "VCAN" }, "b": { "entrez_gene_id": 57616, "symbol": "TSHZ3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.82612748, "benjamini_hochberg_q_conservative": 4.4190500847679065e-304 }, "metabric": { "samples": 1980, "spearman_rho": 0.72642347, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for VCAN (Entrez 1462) and TSHZ3 (Entrez 57616) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 31, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 56833, "symbol": "SLAMF8" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.72296547, "benjamini_hochberg_q_conservative": 1.9796505751242577e-194 }, "metabric": { "samples": 1980, "spearman_rho": 0.7462181, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for SLAMF8 (Entrez 56833) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 32, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 27338, "symbol": "UBE2S" }, "b": { "entrez_gene_id": 113130, "symbol": "CDCA5" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.72151058, "benjamini_hochberg_q_conservative": 3.858541399885692e-193 }, "metabric": { "samples": 1980, "spearman_rho": 0.7465909, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for UBE2S (Entrez 27338) and CDCA5 (Entrez 113130) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 33, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 958, "symbol": "CD40" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.76866244, "benjamini_hochberg_q_conservative": 7.18445562018202e-241 }, "metabric": { "samples": 1980, "spearman_rho": 0.72113951, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CD40 (Entrez 958) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 34, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 54504, "symbol": "CPVL" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.71336707, "benjamini_hochberg_q_conservative": 4.3542459993853165e-186 }, "metabric": { "samples": 1980, "spearman_rho": 0.73858699, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CPVL (Entrez 54504) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 35, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 63940, "symbol": "GPSM3" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.7428741, "benjamini_hochberg_q_conservative": 3.4607443869274535e-213 }, "metabric": { "samples": 1980, "spearman_rho": 0.7129443, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GPSM3 (Entrez 63940) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 36, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3833, "symbol": "KIFC1" }, "b": { "entrez_gene_id": 7153, "symbol": "TOP2A" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70986996, "benjamini_hochberg_q_conservative": 3.7256899157986703e-183 }, "metabric": { "samples": 1980, "spearman_rho": 0.77726075, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for KIFC1 (Entrez 3833) and TOP2A (Entrez 7153) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 37, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 89857, "symbol": "KLHL6" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.71655919, "benjamini_hochberg_q_conservative": 8.05060643084806e-189 }, "metabric": { "samples": 1980, "spearman_rho": 0.7082248, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for KLHL6 (Entrez 89857) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 38, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 5157, "symbol": "PDGFRL" }, "b": { "entrez_gene_id": 57616, "symbol": "TSHZ3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70783159, "benjamini_hochberg_q_conservative": 1.8102162877444352e-181 }, "metabric": { "samples": 1980, "spearman_rho": 0.74046629, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for PDGFRL (Entrez 5157) and TSHZ3 (Entrez 57616) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 39, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 6793, "symbol": "STK10" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70716962, "benjamini_hochberg_q_conservative": 6.367179024108422e-181 }, "metabric": { "samples": 1980, "spearman_rho": 0.71226293, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for STK10 (Entrez 6793) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 40, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 7293, "symbol": "TNFRSF4" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70562136, "benjamini_hochberg_q_conservative": 1.195169575438692e-179 }, "metabric": { "samples": 1980, "spearman_rho": 0.72010452, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for TNFRSF4 (Entrez 7293) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 41, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3627, "symbol": "CXCL10" }, "b": { "entrez_gene_id": 64135, "symbol": "IFIH1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70192037, "benjamini_hochberg_q_conservative": 1.1197984540404001e-176 }, "metabric": { "samples": 1980, "spearman_rho": 0.70128121, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CXCL10 (Entrez 3627) and IFIH1 (Entrez 64135) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 42, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 51316, "symbol": "PLAC8" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.74807168, "benjamini_hochberg_q_conservative": 2.068253703379106e-218 }, "metabric": { "samples": 1980, "spearman_rho": 0.69936246, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for PLAC8 (Entrez 51316) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 43, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 89857, "symbol": "KLHL6" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.69541855, "benjamini_hochberg_q_conservative": 1.4210683908357905e-171 }, "metabric": { "samples": 1980, "spearman_rho": 0.72556544, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for KLHL6 (Entrez 89857) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 44, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 63940, "symbol": "GPSM3" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.69301436, "benjamini_hochberg_q_conservative": 1.0038834092618604e-169 }, "metabric": { "samples": 1980, "spearman_rho": 0.70775771, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GPSM3 (Entrez 63940) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 45, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 4332, "symbol": "MNDA" }, "b": { "entrez_gene_id": 10346, "symbol": "TRIM22" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70517259, "benjamini_hochberg_q_conservative": 2.758912034934907e-179 }, "metabric": { "samples": 1980, "spearman_rho": 0.69143911, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for MNDA (Entrez 4332) and TRIM22 (Entrez 10346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 46, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 10578, "symbol": "GNLY" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.68816832, "benjamini_hochberg_q_conservative": 4.562433740947762e-166 }, "metabric": { "samples": 1980, "spearman_rho": 0.69449998, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GNLY (Entrez 10578) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 47, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 56833, "symbol": "SLAMF8" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70463347, "benjamini_hochberg_q_conservative": 7.456594575521454e-179 }, "metabric": { "samples": 1980, "spearman_rho": 0.68560713, "benjamini_hochberg_q_conservative": 2.7142400541875973e-301 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for SLAMF8 (Entrez 56833) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 48, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 7153, "symbol": "TOP2A" }, "b": { "entrez_gene_id": 113130, "symbol": "CDCA5" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.68514862, "benjamini_hochberg_q_conservative": 7.834788620454503e-164 }, "metabric": { "samples": 1980, "spearman_rho": 0.76317398, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for TOP2A (Entrez 7153) and CDCA5 (Entrez 113130) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 49, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3627, "symbol": "CXCL10" }, "b": { "entrez_gene_id": 10578, "symbol": "GNLY" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.69909514, "benjamini_hochberg_q_conservative": 1.9423113427336487e-174 }, "metabric": { "samples": 1980, "spearman_rho": 0.6836491, "benjamini_hochberg_q_conservative": 1.1812240490062355e-298 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CXCL10 (Entrez 3627) and GNLY (Entrez 10578) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 50, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 54504, "symbol": "CPVL" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.74890173, "benjamini_hochberg_q_conservative": 2.959301325240256e-219 }, "metabric": { "samples": 1980, "spearman_rho": 0.68149243, "benjamini_hochberg_q_conservative": 8.950315022130021e-296 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CPVL (Entrez 54504) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 51, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 958, "symbol": "CD40" }, "b": { "entrez_gene_id": 3108, "symbol": "HLA-DMA" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.72158959, "benjamini_hochberg_q_conservative": 3.303064520828958e-193 }, "metabric": { "samples": 1980, "spearman_rho": 0.68019308, "benjamini_hochberg_q_conservative": 4.6478701286517486e-294 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CD40 (Entrez 958) and HLA-DMA (Entrez 3108) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 52, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 10578, "symbol": "GNLY" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.71547076, "benjamini_hochberg_q_conservative": 6.922920298489455e-188 }, "metabric": { "samples": 1980, "spearman_rho": 0.67976172, "benjamini_hochberg_q_conservative": 1.7157116894446539e-293 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GNLY (Entrez 10578) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 53, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 4332, "symbol": "MNDA" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.76894025, "benjamini_hochberg_q_conservative": 3.453854088293591e-241 }, "metabric": { "samples": 1980, "spearman_rho": 0.67949874, "benjamini_hochberg_q_conservative": 3.747297660836222e-293 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for MNDA (Entrez 4332) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 54, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 9833, "symbol": "MELK" }, "b": { "entrez_gene_id": 23234, "symbol": "DNAJC9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.6843292, "benjamini_hochberg_q_conservative": 3.143613703161698e-163 }, "metabric": { "samples": 1980, "spearman_rho": 0.67914228, "benjamini_hochberg_q_conservative": 1.0972782053196342e-292 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for MELK (Entrez 9833) and DNAJC9 (Entrez 23234) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 55, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 128346, "symbol": "C1orf162" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67614355, "benjamini_hochberg_q_conservative": 2.3519976171527012e-157 }, "metabric": { "samples": 1980, "spearman_rho": 0.70501384, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for C1orf162 (Entrez 128346) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 56, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 330, "symbol": "BIRC3" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67317001, "benjamini_hochberg_q_conservative": 2.7858018502166457e-155 }, "metabric": { "samples": 1980, "spearman_rho": 0.71774762, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for BIRC3 (Entrez 330) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 57, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 6363, "symbol": "CCL19" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67282402, "benjamini_hochberg_q_conservative": 4.851217575232666e-155 }, "metabric": { "samples": 1980, "spearman_rho": 0.6772817, "benjamini_hochberg_q_conservative": 2.9965863073497295e-290 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CCL19 (Entrez 6363) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 58, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 958, "symbol": "CD40" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67259979, "benjamini_hochberg_q_conservative": 6.939075334101149e-155 }, "metabric": { "samples": 1980, "spearman_rho": 0.68308956, "benjamini_hochberg_q_conservative": 6.625542720329038e-298 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CD40 (Entrez 958) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 59, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 56833, "symbol": "SLAMF8" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.78601032, "benjamini_hochberg_q_conservative": 4.2420303393580084e-262 }, "metabric": { "samples": 1980, "spearman_rho": 0.6714251, "benjamini_hochberg_q_conservative": 1.0390820818402236e-282 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for SLAMF8 (Entrez 56833) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 60, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 10578, "symbol": "GNLY" }, "b": { "entrez_gene_id": 56833, "symbol": "SLAMF8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67013184, "benjamini_hochberg_q_conservative": 3.4706169574934455e-153 }, "metabric": { "samples": 1980, "spearman_rho": 0.67877651, "benjamini_hochberg_q_conservative": 3.2993138969857526e-292 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GNLY (Entrez 10578) and SLAMF8 (Entrez 56833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 61, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 7462, "symbol": "LAT2" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.80204388, "benjamini_hochberg_q_conservative": 5.589980247631573e-284 }, "metabric": { "samples": 1980, "spearman_rho": 0.66985266, "benjamini_hochberg_q_conservative": 9.965667810790823e-281 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for LAT2 (Entrez 7462) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 62, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 7462, "symbol": "LAT2" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.80076082, "benjamini_hochberg_q_conservative": 3.889034557368359e-282 }, "metabric": { "samples": 1980, "spearman_rho": 0.66847153, "benjamini_hochberg_q_conservative": 5.416440282722165e-279 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for LAT2 (Entrez 7462) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 63, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 89857, "symbol": "KLHL6" }, "b": { "entrez_gene_id": 150365, "symbol": "MEI1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.78183516, "benjamini_hochberg_q_conservative": 8.60294783617382e-257 }, "metabric": { "samples": 1980, "spearman_rho": 0.66749436, "benjamini_hochberg_q_conservative": 8.755693226049518e-278 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for KLHL6 (Entrez 89857) and MEI1 (Entrez 150365) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 64, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3108, "symbol": "HLA-DMA" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.71306844, "benjamini_hochberg_q_conservative": 7.78353603788277e-186 }, "metabric": { "samples": 1980, "spearman_rho": 0.6662726, "benjamini_hochberg_q_conservative": 2.841103496363214e-276 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HLA-DMA (Entrez 3108) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 65, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" }, "b": { "entrez_gene_id": 160365, "symbol": "CLECL1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.73522882, "benjamini_hochberg_q_conservative": 9.762218839424653e-206 }, "metabric": { "samples": 1980, "spearman_rho": 0.66616934, "benjamini_hochberg_q_conservative": 3.78564773295796e-276 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for ARHGAP9 (Entrez 64333) and CLECL1 (Entrez 160365) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 66, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 1462, "symbol": "VCAN" }, "b": { "entrez_gene_id": 5157, "symbol": "PDGFRL" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67152395, "benjamini_hochberg_q_conservative": 3.854352890686958e-154 }, "metabric": { "samples": 1980, "spearman_rho": 0.66436912, "benjamini_hochberg_q_conservative": 6.218883076410111e-274 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for VCAN (Entrez 1462) and PDGFRL (Entrez 5157) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 67, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 958, "symbol": "CD40" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70015447, "benjamini_hochberg_q_conservative": 2.8371026854638954e-175 }, "metabric": { "samples": 1980, "spearman_rho": 0.66378872, "benjamini_hochberg_q_conservative": 3.1664347706538792e-273 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CD40 (Entrez 958) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 68, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 958, "symbol": "CD40" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70215272, "benjamini_hochberg_q_conservative": 7.311115852109759e-177 }, "metabric": { "samples": 1980, "spearman_rho": 0.6626611, "benjamini_hochberg_q_conservative": 7.385237956685814e-272 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CD40 (Entrez 958) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 69, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 51316, "symbol": "PLAC8" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.65917835, "benjamini_hochberg_q_conservative": 7.205057674358229e-146 }, "metabric": { "samples": 1980, "spearman_rho": 0.691279, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for PLAC8 (Entrez 51316) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 70, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3161, "symbol": "HMMR" }, "b": { "entrez_gene_id": 9833, "symbol": "MELK" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.76821727, "benjamini_hochberg_q_conservative": 2.3372117651507864e-240 }, "metabric": { "samples": 1980, "spearman_rho": 0.65827625, "benjamini_hochberg_q_conservative": 1.4118407798927462e-266 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HMMR (Entrez 3161) and MELK (Entrez 9833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 71, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3108, "symbol": "HLA-DMA" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.70394679, "benjamini_hochberg_q_conservative": 2.651352690993621e-178 }, "metabric": { "samples": 1980, "spearman_rho": 0.65604421, "benjamini_hochberg_q_conservative": 6.353943483979553e-264 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HLA-DMA (Entrez 3108) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 72, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 6160, "symbol": "RPL31" }, "b": { "entrez_gene_id": 6176, "symbol": "RPLP1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.65509485, "benjamini_hochberg_q_conservative": 3.053268993770689e-143 }, "metabric": { "samples": 1980, "spearman_rho": 0.73998846, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for RPL31 (Entrez 6160) and RPLP1 (Entrez 6176) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 73, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 56833, "symbol": "SLAMF8" }, "b": { "entrez_gene_id": 126014, "symbol": "OSCAR" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.65143705, "benjamini_hochberg_q_conservative": 6.300927104779527e-141 }, "metabric": { "samples": 1980, "spearman_rho": 0.67543929, "benjamini_hochberg_q_conservative": 7.449742525898755e-288 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for SLAMF8 (Entrez 56833) and OSCAR (Entrez 126014) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 74, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3161, "symbol": "HMMR" }, "b": { "entrez_gene_id": 113130, "symbol": "CDCA5" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.68399103, "benjamini_hochberg_q_conservative": 5.5503725636526655e-163 }, "metabric": { "samples": 1980, "spearman_rho": 0.65059633, "benjamini_hochberg_q_conservative": 1.4500071425337768e-257 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HMMR (Entrez 3161) and CDCA5 (Entrez 113130) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 75, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 63940, "symbol": "GPSM3" }, "b": { "entrez_gene_id": 89857, "symbol": "KLHL6" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64875832, "benjamini_hochberg_q_conservative": 2.9817175183002666e-139 }, "metabric": { "samples": 1980, "spearman_rho": 0.68578639, "benjamini_hochberg_q_conservative": 1.5644714784835335e-301 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GPSM3 (Entrez 63940) and KLHL6 (Entrez 89857) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 76, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 958, "symbol": "CD40" }, "b": { "entrez_gene_id": 56833, "symbol": "SLAMF8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.68601129, "benjamini_hochberg_q_conservative": 1.837574072835127e-164 }, "metabric": { "samples": 1980, "spearman_rho": 0.64766833, "benjamini_hochberg_q_conservative": 3.247587719301436e-254 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CD40 (Entrez 958) and SLAMF8 (Entrez 56833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 77, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 56833, "symbol": "SLAMF8" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.68874232, "benjamini_hochberg_q_conservative": 1.711548970738462e-166 }, "metabric": { "samples": 1980, "spearman_rho": 0.64681455, "benjamini_hochberg_q_conservative": 2.972344200319781e-253 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for SLAMF8 (Entrez 56833) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 78, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 128346, "symbol": "C1orf162" }, "b": { "entrez_gene_id": 160365, "symbol": "CLECL1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.69349832, "benjamini_hochberg_q_conservative": 4.30300317314962e-170 }, "metabric": { "samples": 1980, "spearman_rho": 0.64657782, "benjamini_hochberg_q_conservative": 5.452971594305402e-253 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for C1orf162 (Entrez 128346) and CLECL1 (Entrez 160365) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 79, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 10578, "symbol": "GNLY" }, "b": { "entrez_gene_id": 654817, "symbol": "NCF1C" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64665311, "benjamini_hochberg_q_conservative": 5.947061929937734e-138 }, "metabric": { "samples": 1980, "spearman_rho": 0.64636889, "benjamini_hochberg_q_conservative": 9.29824105893071e-253 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GNLY (Entrez 10578) and NCF1C (Entrez 654817) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 80, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 10213, "symbol": "PSMD14" }, "b": { "entrez_gene_id": 55854, "symbol": "ZC3H15" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64596966, "benjamini_hochberg_q_conservative": 1.5606995024106233e-137 }, "metabric": { "samples": 1980, "spearman_rho": 0.74779474, "benjamini_hochberg_q_conservative": 1.2897692366740679e-304 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for PSMD14 (Entrez 10213) and ZC3H15 (Entrez 55854) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 81, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3108, "symbol": "HLA-DMA" }, "b": { "entrez_gene_id": 63940, "symbol": "GPSM3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.72592714, "benjamini_hochberg_q_conservative": 4.2730491851875465e-197 }, "metabric": { "samples": 1980, "spearman_rho": 0.64456785, "benjamini_hochberg_q_conservative": 9.79802355273052e-251 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HLA-DMA (Entrez 3108) and GPSM3 (Entrez 63940) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 82, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 6793, "symbol": "STK10" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.66438458, "benjamini_hochberg_q_conservative": 2.631130934497076e-149 }, "metabric": { "samples": 1980, "spearman_rho": 0.64387196, "benjamini_hochberg_q_conservative": 5.900584491629541e-250 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for STK10 (Entrez 6793) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 83, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 5031, "symbol": "P2RY6" }, "b": { "entrez_gene_id": 83706, "symbol": "FERMT3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64364238, "benjamini_hochberg_q_conservative": 4.0660466309343694e-136 }, "metabric": { "samples": 1980, "spearman_rho": 0.6675168, "benjamini_hochberg_q_conservative": 8.279033789898197e-278 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for P2RY6 (Entrez 5031) and FERMT3 (Entrez 83706) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 84, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 23234, "symbol": "DNAJC9" }, "b": { "entrez_gene_id": 113130, "symbol": "CDCA5" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.68229997, "benjamini_hochberg_q_conservative": 9.479524249277086e-162 }, "metabric": { "samples": 1980, "spearman_rho": 0.64312626, "benjamini_hochberg_q_conservative": 3.970049534812368e-249 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for DNAJC9 (Entrez 23234) and CDCA5 (Entrez 113130) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 85, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 27122, "symbol": "DKK3" }, "b": { "entrez_gene_id": 57616, "symbol": "TSHZ3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.69340483, "benjamini_hochberg_q_conservative": 5.059758706021902e-170 }, "metabric": { "samples": 1980, "spearman_rho": 0.64308554, "benjamini_hochberg_q_conservative": 4.383037152362733e-249 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for DKK3 (Entrez 27122) and TSHZ3 (Entrez 57616) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 86, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 3161, "symbol": "HMMR" }, "b": { "entrez_gene_id": 7153, "symbol": "TOP2A" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.75680248, "benjamini_hochberg_q_conservative": 1.3665703802419373e-227 }, "metabric": { "samples": 1980, "spearman_rho": 0.64160687, "benjamini_hochberg_q_conservative": 1.8961596839500167e-247 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for HMMR (Entrez 3161) and TOP2A (Entrez 7153) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 87, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 51316, "symbol": "PLAC8" }, "b": { "entrez_gene_id": 160365, "symbol": "CLECL1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64150843, "benjamini_hochberg_q_conservative": 7.953019728550163e-135 }, "metabric": { "samples": 1980, "spearman_rho": 0.65336996, "benjamini_hochberg_q_conservative": 8.810511755222166e-261 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for PLAC8 (Entrez 51316) and CLECL1 (Entrez 160365) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 88, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 6916, "symbol": "TBXAS1" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67768929, "benjamini_hochberg_q_conservative": 1.9139151867860864e-158 }, "metabric": { "samples": 1980, "spearman_rho": 0.64147847, "benjamini_hochberg_q_conservative": 2.6035996195215356e-247 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for TBXAS1 (Entrez 6916) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 89, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 6358, "symbol": "CCL14" }, "b": { "entrez_gene_id": 54360, "symbol": "CYTL1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.71506248, "benjamini_hochberg_q_conservative": 1.5481141863300003e-187 }, "metabric": { "samples": 1980, "spearman_rho": 0.64063432, "benjamini_hochberg_q_conservative": 2.1964687815514967e-246 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CCL14 (Entrez 6358) and CYTL1 (Entrez 54360) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 90, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 51316, "symbol": "PLAC8" }, "b": { "entrez_gene_id": 128346, "symbol": "C1orf162" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.6405641, "benjamini_hochberg_q_conservative": 2.9437429222863523e-134 }, "metabric": { "samples": 1980, "spearman_rho": 0.66297943, "benjamini_hochberg_q_conservative": 3.060976720974302e-272 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for PLAC8 (Entrez 51316) and C1orf162 (Entrez 128346) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 91, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 5294, "symbol": "PIK3CG" }, "b": { "entrez_gene_id": 81704, "symbol": "DOCK8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.74296536, "benjamini_hochberg_q_conservative": 2.8561781428671556e-213 }, "metabric": { "samples": 1980, "spearman_rho": 0.64043366, "benjamini_hochberg_q_conservative": 3.6414940820783105e-246 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for PIK3CG (Entrez 5294) and DOCK8 (Entrez 81704) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 92, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 4332, "symbol": "MNDA" }, "b": { "entrez_gene_id": 6916, "symbol": "TBXAS1" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.69637539, "benjamini_hochberg_q_conservative": 2.630493018974994e-172 }, "metabric": { "samples": 1980, "spearman_rho": 0.64029028, "benjamini_hochberg_q_conservative": 5.187848098881189e-246 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for MNDA (Entrez 4332) and TBXAS1 (Entrez 6916) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 93, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 57616, "symbol": "TSHZ3" }, "b": { "entrez_gene_id": 116535, "symbol": "MRGPRF" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64022613, "benjamini_hochberg_q_conservative": 4.672762308923893e-134 }, "metabric": { "samples": 1980, "spearman_rho": 0.64233955, "benjamini_hochberg_q_conservative": 2.932790321287792e-248 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for TSHZ3 (Entrez 57616) and MRGPRF (Entrez 116535) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 94, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 5031, "symbol": "P2RY6" }, "b": { "entrez_gene_id": 56833, "symbol": "SLAMF8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64006286, "benjamini_hochberg_q_conservative": 5.850622685723576e-134 }, "metabric": { "samples": 1980, "spearman_rho": 0.67043728, "benjamini_hochberg_q_conservative": 1.831848962051849e-281 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for P2RY6 (Entrez 5031) and SLAMF8 (Entrez 56833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 95, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 2323, "symbol": "FLT3LG" }, "b": { "entrez_gene_id": 64333, "symbol": "ARHGAP9" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.67492314, "benjamini_hochberg_q_conservative": 1.6841329318890202e-156 }, "metabric": { "samples": 1980, "spearman_rho": 0.63934603, "benjamini_hochberg_q_conservative": 5.523039861588121e-245 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for FLT3LG (Entrez 2323) and ARHGAP9 (Entrez 64333) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 96, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 11259, "symbol": "FILIP1L" }, "b": { "entrez_gene_id": 57616, "symbol": "TSHZ3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.75072204, "benjamini_hochberg_q_conservative": 3.879598123476979e-221 }, "metabric": { "samples": 1980, "spearman_rho": 0.63814851, "benjamini_hochberg_q_conservative": 1.1269044901770844e-243 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for FILIP1L (Entrez 11259) and TSHZ3 (Entrez 57616) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 97, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 1075, "symbol": "CTSC" }, "b": { "entrez_gene_id": 56833, "symbol": "SLAMF8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.69597406, "benjamini_hochberg_q_conservative": 5.350043473443899e-172 }, "metabric": { "samples": 1980, "spearman_rho": 0.63798254, "benjamini_hochberg_q_conservative": 1.7030506562333115e-243 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for CTSC (Entrez 1075) and SLAMF8 (Entrez 56833) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 98, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 4330, "symbol": "MN1" }, "b": { "entrez_gene_id": 57616, "symbol": "TSHZ3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.636734, "benjamini_hochberg_q_conservative": 5.4731981031426326e-132 }, "metabric": { "samples": 1980, "spearman_rho": 0.64384873, "benjamini_hochberg_q_conservative": 6.227977564674503e-250 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for MN1 (Entrez 4330) and TSHZ3 (Entrez 57616) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 99, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 1462, "symbol": "VCAN" }, "b": { "entrez_gene_id": 27122, "symbol": "DKK3" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.63653962, "benjamini_hochberg_q_conservative": 7.100509909893893e-132 }, "metabric": { "samples": 1980, "spearman_rho": 0.636519, "benjamini_hochberg_q_conservative": 6.644568788525738e-242 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for VCAN (Entrez 1462) and DKK3 (Entrez 27122) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" }, { "rank": 100, "status": "replicated_computational_observation", "entities": { "a": { "entrez_gene_id": 10578, "symbol": "GNLY" }, "b": { "entrez_gene_id": 51316, "symbol": "PLAC8" } }, "direction": "positive", "tcga": { "samples": 1082, "spearman_rho": 0.64648016, "benjamini_hochberg_q_conservative": 7.597962181584194e-138 }, "metabric": { "samples": 1980, "spearman_rho": 0.63623626, "benjamini_hochberg_q_conservative": 1.340719417828838e-241 }, "generated_claim": "In the pinned TCGA and METABRIC breast-tumour cohorts, expression ranks for GNLY (Entrez 10578) and PLAC8 (Entrez 51316) had a positive association that passed the frozen evidence-v1 replication gates.", "claim_scope": "cohort-level rank-expression association only" } ], "human_dependencies": [], "manual_override_used": false, "llm_interpretation_used": false, "claim_boundary": { "allowed_claim": "a bounded rank-expression association observed in both pinned cohorts under this frozen protocol", "not_a_claim_of": [ "causality", "mechanism", "clinical utility or safety", "cell-intrinsic regulation", "novelty to humanity", "absence of academic or non-academic knowledge", "a validated knowledge-gap detector", "a relation that generalizes beyond these cohorts", "independence from tumour subtype, purity, batch, or cell-composition confounding" ] }, "limitations": [ "A replicated cohort-level correlation can be driven by tumour subtype, purity, batch, stromal or immune composition, copy number, or other shared causes.", "Cross-platform agreement reduces platform-specific risk but does not establish a biological mechanism or cell-intrinsic regulation.", "The deterministic 1,000-gene universe is a score-blind computational subset, not a representative sample of biology.", "cBioPortal's pinned source metadata warns that the TCGA transport is preliminary and should be used with caution.", "Academic corpora and expression cohorts omit or thinly represent non-academic, practitioner, craft, indigenous, historical, and other human knowledge." ], "readiness_contribution": 1 }